As part of the protest, Crimean Tatar activists are expected to stop freight vehicles from carrying food supplies to Crimea.
Under the demands made by the Mejlis leaders, food deliveries to Crimea can only be resumed if human rights there are respected.
The blockade has the support of Ukrainian patriots who have voiced their readiness to help Crimean Tatars.
In the meantime, Sergey Aksyonov, Head of the Council of Ministers of Crimea, assured Crimean residents the blockade would not affect them. He failed to mention though how he would be handling the situation.
It is difficult to foresee how the Russian authorities will be responding to the blockade, but Crimean Tatars will not be taking kindly to any hostile and unlawful acts on their part.